Research Scientist, Molecular Pharmacoloy

Company: Stanford University
Location: Palo Alto
Posted on: November 17, 2023

Job Description:

Research Scientist, Molecular Pharmacology Sarafan ChEM-H is an interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The proximity of world-class biologists, chemists, engineers, and clinicians at Stanford presents a unique opportunity to study human biology at a molecular level, to translate this knowledge into groundbreaking discoveries that advance our understanding of and ability to improve human health. Sarafan ChEM-H has partnered with Stanford Medicine to launch a bold new translational research initiative - Stanford's Innovative Medicines Accelerator (IMA). IMA aims to accelerate the translation of scientific discoveries at Stanford University into new therapeutics that impact human health while improving our understanding of human biology. The Preclinical pharmacology team works closely with the Medicinal Chemistry, High Throughput Screening and Protein Engineering modules.They propel IMA projects with quantitative measurements of drug candidates that guide medicinal chemists and protein engineers toward drug prototypes.Preclinical pharmacology collects information about how drug candidates interact with their targets, affect cells in culture and behave in animals.Preclinical pharmacology informs how drug candidates will behave in humans. Our VPDoR Diversity Journey :

• We create a hub of innovation through the power of diversity of disciplines and people.
• We provide equitable access and opportunity to all members of the community in order to do their best work, regardless of race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
• We listen to and value all colleagues who bring diverse perspectives to the advancement and development of a respectful community.
• We promote a culture of belonging, equity, and safety.
• We embed these values in excellence of education, research, and operation. POSITION SUMMARY: The Stanford Innovative Medicines Accelerator (IMA) is seeking a Research Scientist, Molecular Pharmacology, to perform cell-based assays in support of the IMA's portfolio of drug discovery projects.You will perform and support complex lab experiments working both independently and in collaboration with other Stanford IMA scientists. You have experience and knowledge of a variety of experimental methods used to measure the quantitative interaction between drug candidates and targets. You are an experienced biochemist, cell biologist or immunologist with a solid publication record with a goal of making medicines for the benefit of humankind.You will have a minimum of three years of industry experience in a pharmaceutical or biotechnology company performing cell-based assays for the purpose of discovering new therapeutic molecules.You have experience generating cell lines and using them to perform target-based screening assays to optimize drug potency.You are adept at methods of cell enrichment to obtain specific cell populations (e.g. CD3+ T-cells) for use in mixed cell assays (e.g. T cell killing target cell).You have a good understanding of the basic principles and techniques used in molecular biology and cellular immunology and have demonstrated experience in performing cell-based and biochemical assays. CORE DUTIES:
  • Support complex scientific and research programs related to Molecular Pharmacology and Immunology; analyze data, monitor and oversee experimental processes, and design and develop novel in vitro and cell-based assay systems.
  • Collaborate with scientists, engineers, or senior administrative officers to oversee complex non-routine analyses, select optimum solutions, and perform corrective modifications to assay systems.
  • Carry out all activities, including troubleshooting and resolving routine problems for scientists or engineers, independently.
  • Collaborate with senior engineers and scientists to design and develop special purpose assay systems.
  • Participate in the planning, design, and implementation of scientific or engineering initiatives, and work toward project objectives.
  • Could serve as a resource in review of research proposals and research capabilities and make recommendations.
  • Establish, communicate, and enforce compliance with health and safety policies and procedures.
  • Develop training manuals and safety guidelines, and train new instrumentation users, researchers, and/or technical staff.
  • Perform supervisory duties, including overseeing the work of technicians and other staff associated with the group/project, supervising the regular installation, maintenance, and operation of complex scientific or engineering projects, and training technicians, operators, and others working in particular scientific or engineering function area . MINIMUM REQUIREMENTS: Education & Experience: Bachelors' degree in engineering, science, or related field, or five years of equivalent work experience or combination of education and relevant experience. PREFERRED QUALIFICATIONS:
    • Ph.D. degree in a biotechnology-related field, and at least three years of work experience in the BioTech or Pharmaceutical industry strongly preferred.
    • Outstanding candidates with a B.S. degree could be considered provided they have over ten years experience in the BioTech or Pharmaceutical industry and a solid publication record. Knowledge, Skills and Abilities:
      • Demonstrated knowledge and skills of biochemistry, molecular biology, enzymology and cellular immunology.
      • Extensive experience applying complex scientific and engineering principles and performing special technical services involving both development and performance.
      • In-depth experience with software applications, systems, or programs relevant for the job.
      • Ability to independently oversee and manage instrumentation including plate readers, chromatography systems and cell sorters.
      • Ability to collaborate with senior engineering and scientific staff to design and develop special purpose equipment and/or systems.
      • Experience overseeing the plan, design, and implementation of major scientific or engineering initiatives and ensuring project objective are met.
      • Demonstrated ability to review research proposals, evaluate research capabilities, and make recommendations.
      • Demonstrated ability to establish, communicate, and enforce compliance with health and safety policies and procedures.
      • Experience overseeing a laboratory space or unit and supervising the work of technicians - and other staff associated with the group.
      • Demonstrated ability to effectively supervise and train a diverse work staff. PHYSICAL REQUIREMENTS*:\
        • Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.
        • Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.
        • Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh > 40 pounds. * - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of the job. WORKING CONDITIONS:
          • May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights ?10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather. WORK STANDARDS:
            • Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
            • Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
            • Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu . This position will be on-site. The expected pay range for this position is $109,000 to $129,000 per annum.
              Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs. At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards ) provides detailed information on Stanford's extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process. - Why Stanford is for You Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with:
              • Freedom to grow. We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak.
              • A caring culture. We provide superb retirement plans, generous time-off, and family care resources.
              • A healthier you. Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.
              • Discovery and fun. Stroll through historic sculptures, trails, and museums.
              • Enviable resources. Enjoy free commuter programs, ridesharing incentives, discounts and more! The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.Dean of Research, Stanford, California, United StatesDean of Research, Stanford, California, United StatesDean of Research, Stanford, California, United States
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Keywords: Stanford University, Palo Alto , Research Scientist, Molecular Pharmacoloy, Accounting, Auditing , Palo Alto, California