Senior Manager - Pharmacology, Oncology (Remote)

Company: Jazz Pharmaceuticals
Location: Palo Alto
Posted on: September 12, 2023

Job Description:

If you are a Jazz employee please apply via the Internal Career siteJazz Pharmaceuticals plc (NASDAQ: JAZZ) is a global biopharmaceutical company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases - often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines and novel product candidates, from early- to late-stage development, in neuroscience and oncology. We actively explore new options for patients including novel compounds, small molecules and biologics, and through cannabinoid science and innovative delivery technologies. Jazz is headquartered in Dublin, Ireland and has employees around the globe, serving patients in nearly 75 countries. For more information, please visit www.jazzpharmaceuticals.com and follow @JazzPharma on Twitter. This Job Description provides a summary of the duties and/or characteristic of work performed and is not inclusive of every detail of the job for every individual assigned to the position. This description will be reviewed periodically and revised as duties and responsibilities change with business demands. Other duties not listed above may be assigned as needed.Brief Description:This individual will be responsible for leading oncology non-clinical pharmacology activities in the Oncology Research -- Department. Primary responsibilities of Pharmacology function at Jazz is to establish PK/PD/efficacy relationships and exploring drug mechanism of action, identify predictive disease models and biomarkers, in preclinical settings, to drive the discovery and development of Jazz products and drug candidates. This individual will be able to work independently and within Oncology Research --and project teams to generate study designs, protocols, review and author reports and co-author primary and secondary pharmacodynamics sections of regulatory documents. The scientist is expected to collaborate with external CRO's and internal functional areas including Clinical Development, Project Management, DMPK, Clinical Pharmacology and Toxicology to design, develop and implement strategies to advance non-clinical therapeutics in hematologic cancers and solid tumors.Essential Functions

• Design and execute experiments to elucidate efficacy, tolerability, biomarkers of efficacy and mechanism of action of small molecule drugs and biologics.
• Excellent communication skill with ability to function within --an integrated oncology research program that includes toxicology, DMPK and bioanalytical functions and in matrixed, cross functional teams that represent the full complement of drug development functions.
• Ability to independently design experiments and analyze experimental data and present results in both non-clinical and cross-functional team settings.
• Collaborate with CROs and academic collaborators to outsource studies, design via protocols, manage program timing, and costs and manage data analysis. .
• Experience running biochemical and cellular assays, quantitative analysis and biological sample preparation.
• Serve as oncology development team member and / or leader for major pharmacology activities leading to candidate selection.Required Knowledge, Skills, and Abilities
  • 5-6 years of industry experience in directing or outsourcing preclinical research model development, and investigation of therapeutic potential of drug candidates.
  • Experience with preclinical drug development of oncology therapeutics, in vitro and in vivo models to evaluate mechanism of action, PK/PD, dose response efficacy relationships, predictive and prognostic pharmacodynamic biomarkers and drug mechanism of action in preclinical and clinical settings.
  • Experience with initiation and preclinical development of antibody drug conjugates and antibody based therapies is preferred.
  • Experience working on exploratory prognostic and predictive PD biomarker identification and assessment in preclinical and clinical samples.
  • Experience in managing contract laboratories and sourcing or managing pharmacology programs at a contract laboratory.
  • Possess a core understanding of cancer signaling pathways.
  • Ability to independently design and execute experiments to elucidate efficacy, tolerability, biomarkers of efficacy, mechanism of action of small molecule drugs and biologic products.
  • Experience writing and reviewing non-clinical research reports that are part of submissions to regulatory authorities.
  • Ability to integrate preclinical and clinical data is essential, as is an ability to innovate and apply novel methods to projects.
  • Excellent analytical skills with experience in oncology data analysis.
  • Ability to work effectively both independently and collaboratively in a dynamic, team-oriented environment.
  • Robust working knowledge of MS Office suite of programs, and GraphPad Prism.
    • Strong self-leadership skills, ability to self-start, and desire and competence to network widely within Jazz, the scientific community, and regulatory agencies.
    • Must be detail oriented with strong documentation and organizational skills.
    • Proven ability to oversee academic research, CRO's and consultants.
    • Excellent written and oral communication skills
    • Excellent contingency planning and time management skills and demonstrated ability to manage a number of projects simultaneously.
    • Strong problem solving and analytical skills and be capable of independent and creative thinking.
    • Ability to navigate and be successful in a fast-paced, highly-matrixed work environment.
    • Embody and model Jazz core values.Required/Preferred Education and Licenses
      • Education: Doctoral degree (PhD) in biology, biochemistry or relevant discipline in oncology and 5-6 years of experience developing nonclinical models for the characterization of therapeutic efficacy, MOA and/or pharmacodynamics.Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.FOR US-BASED CANDIDATES ONLYJazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $128,000-$168,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate's qualifications, skills, and experience.At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan.The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here:

Keywords: Jazz Pharmaceuticals, Palo Alto , Senior Manager - Pharmacology, Oncology (Remote), Executive , Palo Alto, California