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Scientist II, Technology Development R&D

Company: Guardant Health
Location: Palo Alto
Posted on: June 24, 2022

Job Description:

Company Description

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has commercially launched Guardant360 -, Guardant360 CDx, Guardant360 TissueNext---, Guardant360 Response---, and GuardantOMNI - tests for advanced stage cancer patients, and Guardant Reveal--- for early-stage cancer patients. These tests fuel development of its screening program, which aims to address the needs of asymptomatic individuals eligible for cancer screening.

Job Description

As a leader in the liquid biopsy field, Guardant Health is seeking a highly motivated scientist to contribute to technology development and implementation in several innovative efforts centered on non-invasive cancer screening. As part of the Research Team within the Screening Division at Guardant Health you will be required to develop and implement novel technologies for early cancer detection within a dynamic, fast-paced and interdisciplinary environment.

As a Scientist II supporting research into innovative assays and technologies for oncology screening and diagnostics, you will interface cross functionally with other teams including bioinformatics, process engineering, and clinical operations. You will be hands-on in the lab and be required to design, implement, and optimize new liquid biopsy assays for the early diagnosis and monitoring of various cancer types. Additionally, you will be encouraged to conduct bioinformatic analysis and interpretation of the data generated in order to quickly and efficiently provide results and conclusions. An integral part of the team is to attend Scientific conferences and thoroughly conduct literature searches and reviews to remain on the cutting edge of technologies and applications in the early cancer detection, prevention, and therapeutic treatment space.

Duties And Responsibilities

  • Develop, test and optimize new nucleic acid-based assays for oncology diagnostics
  • Work in a team environment to identify areas for improvement in NGS assay work streams, then propose and implement solutions
  • Troubleshoot error modes in a research setting
  • Build bioinformatic pipelines for data visualization, interpretation and analysis.
  • Synthesize large datasets and extract relevant trends using NGS data analysis tools (Python, R, IGV)
  • Operate NGS instruments
  • Log and track research samples throughout sequencing workflow
  • Present data, proposals, and progress in various forums and to technical and non-technical audiences
  • Train junior team members
  • Ensure all work is performed and documented in compliance with applicable regulatory and quality practices (CLIA/CAP, IVD (Design Control), ISO13485)

    • PhD in biology, chemistry or related disciplines with 1-2 years industry experience
    • Strong background in molecular biology
    • Solid foundation in laboratory techniques including sample preparation for DNA analysis assays including NGS
    • Proven track record of independent experimental planning, execution and data interpretation
    • Analytical mindset to dissect complex problems, develop hypotheses, test them, synthesize results to inform solutions.
    • Team player who enjoys working in a collaborative environment to accomplish large projects
    • Demonstrated ability to document and communicate scientific data to an interdisciplinary audience
    • Ability to adapt and be successful in a fast-paced environment

      Preferred Skills:
      • Ability to code and generate bioinformatic analyses and pipelines
      • Experience with DNA methylation methods and analysis
      • Experience with cell-free nucleic acid NGS assays
      • Experience with assay development for automated liquid handling platforms
      • Experience with multi-omic NGS assays
      • Experience with single-cell assays (NGS or other)

        Additional Information

        Covid Vaccination Policy: Starting January 7, 2022, Guardant Health will require all employees to be fully vaccinated to either (a) establish that they have been fully vaccinated against COVID-19; or (b) request and obtain an approved exemption from Guardant's COVID-19 U.S. Vaccination Policy as a reasonable accommodation, as consistent with applicable laws. An employee is considered fully vaccinated against COVID-19 two weeks after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination. Acceptable vaccines are approved or under emergency use authorization by the U.S. Food and Drug Administration (FDA) and/or the World Health Organization (WHO). In addition, fully-vaccinated employees will be required to maintain their fully-vaccinated status under this policy by obtaining, if applicable, any FDA-approved boosters.

        Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

        Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

        All your information will be kept confidential according to EEO guidelines.

        To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.

        Please visit our career page at:

Keywords: Guardant Health, Palo Alto , Scientist II, Technology Development R&D, IT / Software / Systems , Palo Alto, California

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