Senior Manager, Pharmacology
Company: Jazz Pharmaceuticals
Location: Palo Alto
Posted on: June 11, 2021
Jazz Pharmaceuticals is a global biopharmaceutical company
dedicated to developing life-changing medicines for people with
serious diseases - often with limited or no options. We have a
diverse portfolio of marketed medicines and novel product
candidates, from early- to late-stage development, in key
therapeutic areas. Our focus is in neuroscience, including sleep
medicine and movement disorders, and in oncology, including
hematologic and solid tumors. We actively explore new options for
patients including novel compounds, small molecule advancements,
biologics and innovative delivery technologies. Jazz is
headquartered in Dublin, Ireland and has employees around the
globe, serving patients in more than 90 countries.
We are looking for the best and brightest talent to join our
team. If you’re looking to be a part of a company with an
unwavering commitment to improving patients’ lives and being a
great place to work, we hope you’ll explore our career openings and
get to know Jazz Pharmaceuticals.
Primary responsibilities of the Pharmacology function at Jazz
are to establish PK/PD/efficacy relationships, explore drug
mechanisms of action, and identify predictive disease models and
biomarkers in preclinical settings. The successful applicant will
play a key role in designing and executing/coordinating in vitro
and in vivo biology/pharmacology studies to evaluate the mechanism
of action of Jazz drug candidates and support identification of
additional indications for clinical stage compounds. This
individual will be able to work independently and within the
Neuroscience Pharmacology group to generate study designs and
protocols, review and author reports and contribute to the
authoring and review of relevant sections of regulatory documents.
The scientist is expected to collaborate with external CRO’s and
internal functional areas including DMPK, Clinical Pharmacology,
and Translational Sciences, to design, develop and implement
strategies to drive the discovery and development of Jazz
neuroscience drug candidates. The qualified candidate may also
participate in diligence activities.
- Design and execute experiments to evaluate efficacy,
tolerability, biomarkers of efficacy and mechanism of action of
Jazz drug candidates.
- Review scientific literature to evaluate possible new models
based on relevant target biology, drug mechanisms of action and
- Collaborate with CROs to outsource in vitro and in vivo biology
and pharmacology studies, and with academic labs and/or partners
for Jazz-sponsored research via design and development of
- Under management guidance, critically review and edit CRO
nonclinical study reports, analyze and interpret data, and
coordinate report finalization.
- Independently drive the execution of preclinical pharmacology
studies in collaboration with CRO’s and academic labs for
Jazz-sponsored research, ensuring compliance with Jazz internal
processes and procedures.
- Contribute to the analysis, interpretation, and visualization
of nonclinical data in preparation for internal
department/team/executive communication, and final study reports.
May represent Neuroscience Pharmacology on matrixed project teams
or internal initiatives.
- Maintain a current understanding of relevant literature and
methodology, as well as the scientific literature related to the
specific Jazz pipeline products and R&D projects.
- Participate in in vivo pharmacology efforts focused on
developing and optimizing relevant animal models to study activity
and PK/PD relationship of candidate compounds
- Embodies and models Jazz Pharmaceuticals core values
(integrity, collaboration, passion, pursuit of excellence and
Required Knowledge, Skills, and Abilities
- Experience in neurology drug discovery and development is
desired; research experience in neurodegenerative diseases,
movement disorders and/or epilepsy is preferred.
- Basic understanding of nervous system anatomy, neurological
circuitry, ion channel and neurotransmitter function, and
mechanisms of CNS drug action is preferred.
- Broad experience with small molecule drug discovery (lead
selection through Phase 1)
- Experience in outsourcing, vendor management, and interfacing
with internal Finance and Legal groups, establishing and managing
consultants and CROs driving timely delivery of clear, accurate,
and well-written nonclinical study data
- Awareness of FDA, EMA, and ICH guidance documents including GLP
- Experience working in small but effective groups as part of
cross-functional teams in highly matrixed organizations
- Ability to synthesize and interpret diverse, multidisciplinary
- Strong verbal communication skills accompanied by scientific
writing skills, with ability to function within Pharmacology and in
matrixed, cross functional teams
- Must be detail oriented with strong quantitative, analytical,
documentation and organizational skills
- Strong working knowledge of MS Office is essential. Experience
working with GraphPad Prism and Microsoft Project is a plus.
Required/Preferred Education and Licenses
Doctoral degree (PhD) in neuroscience, biology, biochemistry or
other relevant discipline and at least 5 years of neuropharmacology
research experience, preferably with at least 2 years of industry
experience. Exceptional candidates with Masters or Bachelors Degree
and necessary experience may be considered.
Jazz Pharmaceuticals is an equal opportunity/affirmative
action employer and all qualified applicants will receive
consideration for employment without regard to race, color,
religion, sex, national origin, disability status, protected
veteran status, or any characteristic protected by law.
Keywords: Jazz Pharmaceuticals, Palo Alto , Senior Manager, Pharmacology, Other , Palo Alto, California
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