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Senior Manager Pharmacology, Neuroscience

Company: Jazz Pharmaceuticals
Location: Palo Alto
Posted on: October 2, 2021

Job Description:

Jazz Pharmaceuticals plc (NASDAQ: JAZZ) is a global biopharmaceutical company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases - often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines and novel product candidates, from early- to late-stage development, in neuroscience and oncology. We actively explore new options for patients including novel compounds, small molecules and biologics, and through cannabinoid science and innovative delivery technologies. Jazz is headquartered in Dublin, Ireland and has employees around the globe, serving patients in nearly 75 countries. For more information, please visit and follow @JazzPharma on Twitter.

This individual will be responsible for performing non-clinical pharmacology activities in the Early Development (ED) Department. Primary responsibilities of Pharmacology function at Jazz is to establish PK/PD/efficacy relationships and exploring drug mechanism of action, identify predictive disease models and biomarkers, in preclinical settings, to drive the discovery and development of Jazz products and drug candidates. This individual will be able to work independently and within ED and project teams to generate study designs, protocols, review and author reports and co-author primary and secondary pharmacodynamics sections of regulatory documents.  The scientist is expected to collaborate with external CRO’s and internal functional areas including Clinical Pharmacology,  Translational Sciences, Project Management,  and Toxicology to design, develop and implement strategies to advance non-clinical studies in areas of Neuroscience. Knowledge of CNS pharmacology and CNS disease mechanisms is highly preferred.

Essential Function

  • Design and oversee the execution of experiments to elucidate efficacy, tolerability, biomarkers of efficacy and mechanism of action of small molecule drugs for CNS indications.
  • Ability to review and critically evaluate scientific literature, develop independent hypotheses and design appropriate scientific experiments to test the hypotheses.
  • Guide the selection and development of preclinical models of disease at CRO’s or academic labs; Collaborate with CROs to design studies through protocol development, trouble-shooting experiments, management of program timing, and costs and collaborate with academic labs for Jazz-sponsored research.
  • Ability to analyze experimental data and present results and interpretation in team settings.
  • Excellent communication skill with ability to function within ED and in matrixed, cross-functional teams.
  • Experience in vivo behavioral models, EEG-based assessments, quantitative analysis and biological sample preparation. Prior experience in sleep pharmacology is a plus.
  • Serve as ED team member and/or lead major pharmacology activities.

Required Knowledge, Skills, and Abilities 

  • 3+ years of industry experience in conducting preclinical research studies to examine the therapeutic potential of drug candidates.
  • Intellectual curiosity, strong problem solving and critical thinking skills; must be capable of independent and creative thinking.
  • Good understanding and knowledge of preclinical models for CNS disease indications.
  • General awareness of the drug development process, particularly early stage development of molecules for CNS indications.
  • Experience in sourcing or managing pharmacology programs at a contract laboratory or at an academic lab.
  • Experience with development of disease models for CNS indications to evaluate drug mechanism of action, PK/PD relationships and biomarker identification in clinical and preclinical studies.
  • Ability to integrate preclinical and clinical data is essential, as is an ability to innovate and apply novel methods to projects.
  • Excellent analytical skills with experience in data analysis and interpretation; experience with GraphPad Prism.
  • Ability to work effectively both independently and collaboratively in a dynamic, team-oriented environment.
  • Strong self-leadership skills, high ability to self-start, Must be detail oriented with strong documentation and organizational skills.
  • Excellent contingency planning, time management skills and demonstrated ability to manage a number of projects simultaneously.
  • Ability to navigate and be successful in a fast-paced, highly-matrixed work environment.

 Required/Preferred Education and Licenses:

 Education: Ph.D. in Neuroscience, Pharmacology, Physiology or related discipline with 3+ years of industry experience in nonclinical development.

Description of Physical Demands:

• Routine mobility within office environment.

• Routine sitting for extended periods.

• Travel to oversee outsourced activities.

• Operating a computer, printer, telephone and other similar office machinery.

Description of Work Environment:

• Work indoors in normal office environment with little exposure to excessive noise, dust, fumes, vibrations and temperature changes.

•Frequent computer use at workstation. •

•May move from one work location to another occasionally.

• Responsibilities may require a work schedule that may include working outside of “normal” work hours, in order to meet business demands.

• Occasional public contact requiring appropriate business apparel.  

Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.

Keywords: Jazz Pharmaceuticals, Palo Alto , Senior Manager Pharmacology, Neuroscience, Other , Palo Alto, California

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