Jazz Pharmaceuticals plc (NASDAQ: JAZZ) is a global
biopharmaceutical company whose purpose is to innovate to transform
the lives of patients and their families. We are dedicated to
developing life-changing medicines for people with serious diseases
- often with limited or no therapeutic options. We have a diverse
portfolio of marketed medicines and novel product candidates, from
early- to late-stage development, in neuroscience and oncology. We
actively explore new options for patients including novel
compounds, small molecules and biologics, and through cannabinoid
science and innovative delivery technologies. Jazz is headquartered
in Dublin, Ireland and has employees around the globe, serving
patients in nearly 75 countries. For more information, please visit
www.jazzpharmaceuticals.com and follow @JazzPharma on Twitter.
This individual will be responsible for performing non-clinical
pharmacology activities in the Early Development (ED) Department.
Primary responsibilities of Pharmacology function at Jazz is to
establish PK/PD/efficacy relationships and exploring drug mechanism
of action, identify predictive disease models and biomarkers, in
preclinical settings, to drive the discovery and development of
Jazz products and drug candidates. This individual will be able to
work independently and within ED and project teams to generate
study designs, protocols, review and author reports and co-author
primary and secondary pharmacodynamics sections of regulatory
documents. The scientist is expected to collaborate with
external CRO’s and internal functional areas including Clinical
Pharmacology, Translational Sciences, Project
Management, and Toxicology to design, develop and implement
strategies to advance non-clinical studies in areas of
Neuroscience. Knowledge of CNS pharmacology and CNS disease
mechanisms is highly preferred.
- Design and oversee the execution of experiments to elucidate
efficacy, tolerability, biomarkers of efficacy and mechanism of
action of small molecule drugs for CNS indications.
- Ability to review and critically evaluate scientific
literature, develop independent hypotheses and design appropriate
scientific experiments to test the hypotheses.
- Guide the selection and development of preclinical models of
disease at CRO’s or academic labs; Collaborate with CROs to design
studies through protocol development, trouble-shooting experiments,
management of program timing, and costs and collaborate with
academic labs for Jazz-sponsored research.
- Ability to analyze experimental data and present results and
interpretation in team settings.
- Excellent communication skill with ability to function within
ED and in matrixed, cross-functional teams.
- Experience in vivo behavioral models, EEG-based assessments,
quantitative analysis and biological sample preparation. Prior
experience in sleep pharmacology is a plus.
- Serve as ED team member and/or lead major pharmacology
Required Knowledge, Skills, and Abilities
- 3+ years of industry experience in conducting preclinical
research studies to examine the therapeutic potential of drug
- Intellectual curiosity, strong problem solving and critical
thinking skills; must be capable of independent and creative
- Good understanding and knowledge of preclinical models for CNS
- General awareness of the drug development process, particularly
early stage development of molecules for CNS indications.
- Experience in sourcing or managing pharmacology programs at a
contract laboratory or at an academic lab.
- Experience with development of disease models for CNS
indications to evaluate drug mechanism of action, PK/PD
relationships and biomarker identification in clinical and
- Ability to integrate preclinical and clinical data is
essential, as is an ability to innovate and apply novel methods to
- Excellent analytical skills with experience in data analysis
and interpretation; experience with GraphPad Prism.
- Ability to work effectively both independently and
collaboratively in a dynamic, team-oriented environment.
- Strong self-leadership skills, high ability to self-start, Must
be detail oriented with strong documentation and organizational
- Excellent contingency planning, time management skills and
demonstrated ability to manage a number of projects
- Ability to navigate and be successful in a fast-paced,
highly-matrixed work environment.
Required/Preferred Education and Licenses:
Education: Ph.D. in Neuroscience, Pharmacology, Physiology
or related discipline with 3+ years of industry experience in
Description of Physical Demands:
• Routine mobility within office environment.
• Routine sitting for extended periods.
• Travel to oversee outsourced activities.
• Operating a computer, printer, telephone and other similar
Description of Work Environment:
• Work indoors in normal office environment with little exposure
to excessive noise, dust, fumes, vibrations and temperature
•Frequent computer use at workstation. •
•May move from one work location to another occasionally.
• Responsibilities may require a work schedule that may include
working outside of “normal” work hours, in order to meet business
• Occasional public contact requiring appropriate business
Jazz Pharmaceuticals is an equal opportunity/affirmative
action employer and all qualified applicants will receive
consideration for employment without regard to race, color,
religion, sex, national origin, disability status, protected
veteran status, or any characteristic protected by law.