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Bioinformatics Scientist, Minimal Residual Disease

Company: Guardant Health
Location: Palo Alto
Posted on: November 23, 2022

Job Description:

Company Description
Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360 -, Guardant360 CDx and GuardantOMNI - tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.
Job Description
Guardant's Reveal project is applying cutting-edge methods in next-generation sequencing (NGS) to develop blood-based, non-invasive approaches to detect minimal residual disease after curative intent therapy and monitor for cancer recurrence. Reveal seeks to leverage Guardant's leadership in the field of liquid biopsy to address a core unmet need in clinical cancer care. Its success is being driven by a team of highly-motivated experts such as yourself, passionate about the potential to revolutionize the field of cancer diagnosis and management thus saving patient lives.
As a member of the Reveal team, you'll be responsible for optimizing and improving Guardant's cancer recurrence detection assay by designing critical experiments and analyzing the resulting data. You will also work to develop appropriate quality control metrics to monitor assay performance. This will require summarizing and presenting data to a diverse audience of functional teams, making recommendations leading to assay improvements. You'll be working closely with multiple functional teams - including laboratory scientists, software engineers, and testing and quality engineers - providing excellent opportunities to interact with and learn from a large number of specialists.

  • PhD in bioinformatics, computational biology, molecular biology, cancer genomics or related fields, or M.S. and 3+ years relevant experience
  • Strong understanding of molecular biology and genomics
  • Proficiency in Python for experimental data analysis, statistical methods, and visualization
  • Expertise in next-generation sequencing data generation and processing - from raw reads to biological insight
  • Excellent communication and presentation skills, ability work across functional teams
  • Ability to make a difference in a fast-paced startup environment
  • Preferred
  • Experience in cancer biology
  • Wet lab and experimental design experience
  • Experience using distributed, high-performance computing Linux environments
    Additional Information
    Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.
    Covid Vaccination Policy: Starting January 7, 2022, Guardant Health will require all employees to be fully vaccinated to either (a) establish that they have been fully vaccinated against COVID-19; or (b) request and obtain an approved exemption from Guardant's COVID-19 U.S. Vaccination Policy as a reasonable accommodation, as consistent with applicable laws. An employee is considered fully vaccinated against COVID-19 two weeks after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination. Acceptable vaccines are approved or under emergency use authorization by the U.S. Food and Drug Administration (FDA) and/or the World Health Organization (WHO). In addition, fully-vaccinated employees will be required to maintain their fully-vaccinated status under this policy by obtaining, if applicable, any FDA-approved boosters.
    Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.
    Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to
    Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
    All your information will be kept confidential according to EEO guidelines.
    To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.
    Please visit our career page at:

Keywords: Guardant Health, Palo Alto , Bioinformatics Scientist, Minimal Residual Disease, Other , Palo Alto, California

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